December 12, 1847

Cover vol. 12, no. 6, December 2015

Granada , Spain December 12 th - 15 th

s 16 location of Presentations 15

Persian-translation vol. 12, no. 6, December 2015

Mathias Mayor (1775–1847)

Steno's inability to explain an affair of the soul such as pain in terms of the impact of matter reveals the dualist split between science and religion which makes itself increasingly perceptible at the time and seems to have troubled him fundamentally. Had earlier scientific men such as Harvey and Van Helmont been perhaps happier in their monist view of the world and of the 'working-matter' in...

Dmd065748 1847..1854

The mechanism by which drugs inhibit organic anion transporter 1 (OAT1) was examined. OAT1 was stably expressed in Chinese hamster ovary (CHO) cells, and para-aminohippurate (PAH) and 6-carboxyfluorescein were the substrates. Most compounds (10 of 14) inhibited competitively, increasing the Michaelis constant (Km) without affecting the maximal transport rate (Jmax). Others were mixed-type (lowe...